Macrodasines A—G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran—tetrahydrofuran and tetrahydrofuran—tetrahydropyran rings

Authors

T.S. KamFollow
S.J. Tan
W.T. Robinson
K. Komiyama

Document Type

Article (Restricted)

Publication Date

1-1-2011

Abstract

The bark extract of the Malayan Alstonia angustifoliaWall provided the spirocyclic alkaloids macrodasines A—G. The structures of the new compounds were established by analysis of the spectroscopic data and in the case of macrodasines A and B confirmed by X-ray diffraction analysis. Macrodasines A, B, C, and G incorporate fused spirocyclic tetrahydrofuran—tetrahydrofuran rings, while macrodasines D, E, and F incorporate fused tetrahydrofuran—tetrahydropyran rings. Macrodasines B, C, and E were found to show moderate levels of activity in reversing multidrug-resistance in drug-resistant KB cells.

Keywords

Spirocyclic alkaloids, NMR, X-ray, Alstonia.

Divisions

CHEMISTRY

Publication Title

Tetrahedron

Volume

67

Publisher

Elsevier

Additional Information

Department of Chemistry, University of Malaya