Document Type
Article (Restricted)
Publication Date
1-1-2011
Abstract
Three new indole alkaloids (1—3), named grandilodines A—C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established usingNMRand MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.
Keywords
Alkaloids, Kopsia grandifolia, Venalstonine, Lapidilectine.
Divisions
CHEMISTRY
Publication Title
Journal of Natural Products
Volume
74
Publisher
American Chemical Society and American Society of Pharmacognosy
Additional Information
Department of Chemistry, University of Malaya
COinS