From legacy to innovation: A comprehensive review of vaccine platforms against viral infections

Document Type

Review

Publication Date

6-1-2026

Abstract

Viral infections continue to pose a substantial global health concern, resulting in extensive morbidity and mortality among various populations. Although conventional vaccinations have been pivotal in managing and eliminating certain viral infections, the introduction of new viruses and the resurgence of existing ones underscore the ongoing necessity for creative immunization techniques. This review offers an extensive examination of both conventional and novel vaccine platforms for preventing viral diseases. It analyzes traditional approaches such as inactivated and attenuated vaccines in conjunction with innovative technologies, including subunit, viral vector-based, DNA, mRNA, and virus-like particle (VLP) vaccines. Furthermore, novel strategies to enhance vaccination efficacy, including nanoparticle-based and plant-derived vaccines, are examined. Each platform is evaluated according to its mode of action, immunogenicity, safety, scalability, and adaptation to novel threats. Empirical instances, especially observations from the COVID-19 pandemic, are employed to underscore the achievements, obstacles, and pragmatic utilization of these tools. By reviewing the scientific foundations and developmental pathways of diverse vaccine strategies, this paper offers a more profound understanding of the evolving landscape of viral vaccine development. Finally, this review emphasizes the critical role of innovation in strengthening global readiness for current and future outbreaks.

Keywords

mRNA vaccines, Nanoparticles, Plants, Vaccination/methods, Viral vector vaccines, Virus-like particles

Publication Title

Virus Research

ISSN

0168-1702

DOI

10.1016/j.virusres.2026.199730

Volume

368

Publisher

Elsevier

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