Application of nitrogen-rich porous organic polymer for the solid-phase synthesis of 2-amino-4H-benzo[b]pyran scaffolds using ball milling process
Document Type
Article
Publication Date
1-1-2021
Abstract
Abstract: This paper presents the efficient synthesis of 2-amino-4H-benzo[b]pyrans using mesoporous poly-melamine-formaldehyde as a polymeric heterogeneous catalyst. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of substituted 2-amino-4H-benzo[b]pyrans were obtained in good to excellent yields under eco-friendly conditions. Other advantages of the current methodology include short reaction time, wide substrate-scope, and use of a metal-free polymeric catalyst. Also, the current method avoids the use of hazardous reagents and solvents, tedious workup and multi-step purification. This work revealed that porous organic polymers containing Lewis base sites having acceptor-donner hydrogen bonding functional groups, and high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid-phase synthesis. Graphic abstract: [Figure not available: see fulltext.] © 2020, Springer Nature Switzerland AG.
Keywords
Condensation, Heterocycles, Heterogeneous catalysis, Porous polymer, Waste prevention
Divisions
nanotechnology
Funders
High Impact Research Grant (NANOCAT RU001-2019) for Scientific Research from University of Malaya, Malaysia
Publication Title
Molecular Diversity
Volume
25
Issue
1
Publisher
Kluwer (now part of Springer)