Antibody levels of COVID-19 vaccine: A comparison between healthy subjects and psychiatric patients on antidepressants
Document Type
Article
Publication Date
1-1-2022
Abstract
This study compares the serological antibody level post-COVID-19 vaccine among healthy subjects and psychiatric patients on antidepressant therapy. It also examines the difference in antidepressants’ side effects experienced by psychiatric patients following the completion of two vaccine doses. A comparative posttest quasi-experimental study was conducted among healthy subjects and psychiatric patients on antidepressant medication in a teaching hospital in Malaysia. Elecsys Anti-SARS-CoV-2 assay was used to detect the antibody titre between weeks 4 and 12 post vaccination. The antidepressant side-effect checklist (ASEC) was used to monitor the occurrence of antidepressant-related side effects pre-and post-vaccination. 24 psychiatric patients and 26 healthy subjects were included. There was no significant difference in the antibody level between the patients (median = 1509 u/ml) and the healthy subjects (median = 995 u/ml). There was no significant worsening in the antidepressant-related side effects. The antibody level post-COVID-19 vaccine did not differ significantly between patients on antidepressant therapy and healthy subjects. Additionally, there was no change in the antidepressant side effects experienced by the patients following the completion of the vaccine. © 2022, Research Trends (P) LTD.. All rights reserved.
Keywords
Agomelatine, Antidepressant agent, Escitalopram, Mirtazapine, Receptor binding domain, SARS-CoV-2 vaccine, Sertraline, Tozinameran, Unclassified drug, Virus spike protein, Vortioxetine, Adult, Antibody blood level, Antibody response, Antibody titer, Antidepressant activity, Article, Blurred vision, Clinical article, Comparative study, Constipation, Controlled study, Coronavirus disease 2019, Decreased appetite, Diarrhea, Disorientation, Educational status, Employment status, Female, Headache, Heart palpitation, Human, Immune response, Insomnia, Male, Mental disease, Nausea and vomiting, Quasi experimental study, Seroprevalence, Sexual dysfunction, Somnolence, Sweating, Tremor, Vaccination, Xerostomia
Divisions
psychological
Funders
None
Publication Title
Current Topics in Pharmacology
Volume
26
Publisher
Research Trends (P) Ltd.
Additional Information
Cited by: 0