Cyclic Polyketides with alpha-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study
Document Type
Article
Publication Date
10-1-2021
Abstract
A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A ( 1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro alpha-glucosidase inhibition activity. Among them, compounds 3-4 showed potent alpha-glucosidase inhibition activity with IC50 value at 11.9 +/- 2.0 mu M and 19.7 +/- 1.5 mu M, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro alpha-glucosidase enzyme inhibition activity results.
Keywords
Endiandra kingiana, Cyclic polyketides, Endiandric acids, Kingianins, Alpha-glucosidase inhibition, Molecular docking
Divisions
CHEMISTRY
Funders
Universiti Sains Malaysia Research Grant RUI [1001.PKIMIA.8012310],Ministry of Higher Education FRGS [FRGS/1/2019/STG01/UMT/03/2]
Publication Title
Records of Natural Products
Volume
15
Issue
5
Publisher
ACG Publications
Publisher Location
YENIKENT MAHALLESI, FIRAT CADDESI, 1-3, GEBZE-KOCAELI, 41400, TURKEY