Synthesis of indolostilbenes via FeCl3-promoted oxidative cyclisation and their biological effects on NG108-15 cell viability and H2O2-induced cytotoxicity
Document Type
Article
Publication Date
1-1-2021
Abstract
A convenient and simple radical cation cyclisation of 3,5-dimethoxystilbene was developed using the commercially available FeCl3under mild condition. It enabled the construction of a new class of indolostilbenes (i.e., indole-stilbene hybrid). Various parameters were investigated to obtain better yields (more than 42) compared with the previously reported. The synthesised indolostilbenes were characterised, and their mechanism of formation was discussed. The synthesised compounds were submitted for biological assay on NG108-15 cell viability and H2O2-induced cytotoxicity. The result showed that two indolostilbenes have promising protective activity against H2O2. © Penerbit Universiti Sains Malaysia, 2021. This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
Keywords
Indolostilbene, FeCl3 oxidative coupling, Pericyclic reaction, H2O2 protective properties, Cyclisation
Divisions
Science
Funders
MyPair PHC Hibiscus[203.PKIMIA. 6782002],Universiti Sains Malaysia Fellowship Scheme
Publication Title
Journal of Physical Science
Volume
32
Issue
1
Publisher
Penerbit Universiti Sains Malaysia