Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses
Document Type
Article
Publication Date
7-1-2022
Abstract
Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and H. pylori, by summarizing H. pylori recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells.
Keywords
Helicobacter pylori, Innate immune activation, Pattern recognition receptors, TLRs, CLRs, NLRs, RLRs, Macrophages
Divisions
fac_med,medicinedept
Funders
Malaysia Ministry of Higher Education Fundamental Research Grant Scheme (Grant No: FRGS/1/2019/SKK06/UM/02/4 (FP133-2019A)),Institut Merieux Young Investigator Fund (Grant No: IF039-2017),Malaysia Public Service Department
Publication Title
International Journal of Molecular Sciences
Volume
23
Issue
14
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND