Zika virus vaccine: The current state of affairs and challenges posed by antibody-dependent enhancement reaction

Authors

• Heng Choon Cheong
• Yi Ying Cheok
• Yee Teng Chan
• Sofiah Sulaiman
• Chung Yeng Looi
• Ahmed F. Alshanon
• Jamiyah Hassan
• Sazaly Abu BakarFollow
• Won Fen WongFollow

Document Type

Article

Publication Date

11-1-2022

Abstract

Infection caused by the Zika virus (ZIKV) can lead to serious neurological complications such as microcephaly in neonates. At present, no approved ZIKV vaccine is available, but few vaccine candidates are undergoing clinical trial. One major challenge faced is antibody-dependent enhancement (ADE) reaction that may provoke severe outcome in subsequent infection by ZIKV or other flaviviruses. Thus, more efforts should be dedicated to understanding ADE in designing a safe and effective vaccine to minimize the consequence of the potentially fatal infection's complications and to tackle potential ZIKV reemergence. This review discusses different types of ZIKV vaccine candidates that are currently underway in various stages of preclinical and clinical evaluations.

Keywords

Antibody-dependent enhancement, Humoral immunity, Pathogenesis, Vaccines, Zika virus

Publication Title

Viral Immunology

Recommended Citation

Cheong, Heng Choon; Cheok, Yi Ying; Chan, Yee Teng; Sulaiman, Sofiah; Looi, Chung Yeng; Alshanon, Ahmed F.; Hassan, Jamiyah; Abu Bakar, Sazaly; and Wong, Won Fen, "Zika virus vaccine: The current state of affairs and challenges posed by antibody-dependent enhancement reaction" (2022). Research Publications (2021 to 2025). 1696.
https://knova.um.edu.my/research_publications_2021_2025/1696

Divisions

fac_med,tidrec

Funders

None

Volume

35

Issue

9

Publisher

Mary Ann Liebert, Inc

Publisher Location

140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA