Carboxylated nanocellulose dispersed nitrogen doped graphene nanosheets and sodium dodecyl sulfate modified electrochemical sensor for the simultaneous determination of paracetamol and naproxen sodium

Document Type

Article

Publication Date

5-1-2022

Abstract

An innovative electrochemical sensing platform was fabricated for the simultaneous determination of paracetamol (PCT) and naproxen sodium (NPX). The glassy carbon electrode (GCE) was modified with a hybrid porous nanocomposite of carboxylated nanocellulose (CNCS), nitrogen doped graphene (NDG) and an anionic surfactant sodium dodecyl sulfate (SDS) by simple ultrasonication and drop-casting method. The (CNCS-NDG)-SDS nanocomposite showed high electrocatalytic performance towards the redox reaction of PCT and the oxidation of NPX between 0.2 V and 0.9 V at 0.1 V s- 1 with broad linear ranges from 0.01 to 90 mu M and 0.1 to 60 mu M for PCT and NPX, respectively. The limit of detection is 0.0015 mu M and 0.0018 mu M for PCT and NPX, respectively, while the limit of quantification is 0.015 mu M and 0.018 mu M, respectively. The (CNCS-NDG)-SDS/GCE sensor showed good stability, reproducibility and repeatability for the electrochemical determination of PCT and NPX.

Keywords

Electrochemical sensor, TEMPO, Carboxylated-nanocellulose, Nitrogen doped graphene, Sodium dodecyl sulfate

Publication Title

Measurement

Divisions

CHEMISTRY,nanocat

Funders

University Malaya Kuala Lumpur,Ministry of Higher Education (MOHE) Malaysia [Grant No; IIRG010B-2019, RU001-2020],Federal Government of Nigeria,Management of Federal University of Lafia

Volume

194

Publisher

Elsevier

Publisher Location

THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND

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