A metal free nanosensor based on nanocellulose-polypyrrole matrix and single-walled carbon nanotube: Experimental study and electroanalytical application for determination of paracetamol and ciprofloxacin
Document Type
Article
Publication Date
12-1-2022
Abstract
In the present work, a highly selective and metal-free electrochemical sensor was fabricated from the fusion of nanocellulose and polypyrrole (NNC-PPY), incorporated with single-walled carbon nanotubes (SWCNTs) via drop-casting method for the simultaneous determination of paracetamol (PCM) and ciprofloxacin (CPR). The screen printed electrode (SPE) modified with NNC-PPY/SWCNTs shows outstanding electrocatalytic performance towards the redox reaction of PCM and oxidation of CPR. The nanocomposite was investigated by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), differential thermal analysis (DTA) and Brunauer-Emmett-Teller (BET) analysis, while the electrochemical performances were investigated by cyclic voltammetry (CV), square-wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). The molecular interactions and binding energy of the prepared NNC-PPY/SWCNTs nanocomposite with PCM and CPR were studied by molecular dynamic simulation (MDs). The fabricated NNC-PPY/SWCNTs/SPE sensor showed dynamic linear range of 0.05–40.0 µM and 1–50 µM for PCM and CPR and a limit of detection (LOD) of 0.072 nM and 0.196 nM, with high sensitivity of 50.341 µA µM−1 cm−2 and 18.610 µA µM−1 cm−2, for PCM and CPR respectively. Furthermore, this fabricated sensor was implemented successfully for the simultaneous determination of PCM and CPR from water samples, biological fluids and pharmaceutical preparations. © 2022 Elsevier B.V.
Keywords
Ciprofloxacin, Molecular dynamic simulation, Nanocellulose – polypyrrole, Paracetamol, Screen printed electrode, Single-walled carbon nanotubes
Divisions
CHEMISTRY,nanocat
Funders
Ministry of Higher Education, Malaysia [Grant No: IIRG010B-2019, NANOCAT-2020],Universiti Malaya
Publication Title
Environmental Nanotechnology Monitoring and Management
Volume
18
Publisher
Elsevier