A comprehensive review of natural products as therapeutic or chemopreventive agents against head and neck squamous cell carcinoma cells using preclinical models

Document Type

Article

Publication Date

9-1-2023

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that arises from the epithelium lining of the oral cavity, hypopharynx, oropharynx, and larynx. Despite the advancement of current treatments, including surgery, chemotherapy, and radiotherapy, the overall survival rate of patients afflicted with HNSCC remains poor. The reasons for these poor outcomes are due to late diagnoses and patient-acquired resistance to treatment. Natural products have been extensively explored as a safer and more acceptable alternative therapy to the current treatments, with numerous studies displaying their potential against HNSCC. This review highlights preclinical studies in the past 5 years involving natural products against HNSCC and explores the signaling pathways altered by these products. This review also addresses challenges and future directions of natural products as chemotherapeutic and chemoprevention agents against HNSCC.

Keywords

Head and neck squamous cell carcinoma, Natural products, Phytochemicals, Chemotherapeutics, Chemoprevention

Publication Title

Biomedicines

Divisions

Dentistry

Funders

UK Research and Innovation [Grant no. 105603]

Volume

11

Issue

9

Publisher

MDPI

Publisher Location

ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND

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