Neuroprotective activities of new monoterpenoid indole alkaloid from nauclea officinalis

Authors

• Sook Yee LiewFollow
• Wen Qi Mak
• Hin Yee Thew
• Kooi Yeong Khaw
• Hazrina HazniFollow
• Marc Litaudon
• Khalijah Awang

Document Type

Article

Publication Date

3-1-2023

Abstract

Phytochemical investigation on the bark of Nauclea officinalis led to the isolation of a new monoterpenoid indole alkaloid, nauclediol. The structure of the compound was identified through extensive spectroscopic analysis. Nauclediol displayed cholinesterase-inhibitory activities towards AChE and BChE with IC50 values of 15.429 and 8.756 mu M, respectively. Statistical analysis revealed that the mode of inhibition of nauclediol was non-competitive inhibitor for both AChE and BChE. Molecular docking revealed that nauclediol interacts with the choline-binding site and the catalytic triad of TcAChE and hBChE. This study also demonstrated the neuroprotective potential of nauclediol against amyloid beta-induced cytotoxicity and LPS-induced neuroinflammation activity in a dose-dependent manner.

Keywords

Nauclea officinalis, Indole alkaloids, Amyloid beta, Neuroinflammation, Cholinesterase

Publication Title

Processes

Recommended Citation

Liew, Sook Yee; Mak, Wen Qi; Thew, Hin Yee; Khaw, Kooi Yeong; Hazni, Hazrina; Litaudon, Marc; and Awang, Khalijah, "Neuroprotective activities of new monoterpenoid indole alkaloid from nauclea officinalis" (2023). Research Publications (2021 to 2025). 2716.
https://knova.um.edu.my/research_publications_2021_2025/2716

Divisions

foundation,cenar

Volume

11

Issue

3

Publisher

MDPI

Publisher Location

ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND