Neuroprotective activities of new monoterpenoid indole alkaloid from nauclea officinalis
Document Type
Article
Publication Date
3-1-2023
Abstract
Phytochemical investigation on the bark of Nauclea officinalis led to the isolation of a new monoterpenoid indole alkaloid, nauclediol. The structure of the compound was identified through extensive spectroscopic analysis. Nauclediol displayed cholinesterase-inhibitory activities towards AChE and BChE with IC50 values of 15.429 and 8.756 mu M, respectively. Statistical analysis revealed that the mode of inhibition of nauclediol was non-competitive inhibitor for both AChE and BChE. Molecular docking revealed that nauclediol interacts with the choline-binding site and the catalytic triad of TcAChE and hBChE. This study also demonstrated the neuroprotective potential of nauclediol against amyloid beta-induced cytotoxicity and LPS-induced neuroinflammation activity in a dose-dependent manner.
Keywords
Nauclea officinalis, Indole alkaloids, Amyloid beta, Neuroinflammation, Cholinesterase
Divisions
foundation,cenar
Publication Title
Processes
Volume
11
Issue
3
Publisher
MDPI
Publisher Location
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND