Current tools for the diagnosis and detection of spotted fever group Rickettsia
Document Type
Article
Publication Date
6-1-2021
Abstract
Spotted fever group (SFG) rickettsiae causes a number of diseases in humans worldwide, which can range from mild to highly lethal. Since the clinical presentations of rickettsioses caused by SFG rickettsiae are variable and may be similar to the diseases caused by other rickettsiae, such as Orientia tsutsugamushi (agent for scrub typhus), Coxiella burnetii (agent for Q fever) and the typhus group rickettsiae (agents for epidemic and murine typhus), the accurate diagnosis of infections caused by SFG Rickettsia remains challenging especially in resource-poor settings in developing countries. This review summarizes the various diagnostic and detection tools that are currently available for the confirmation of infections by SFG rickettsiae. The advantages and challenges pertaining to the different serological and molecular detections methods, as well as new assays in development, are discussed. The utility of the detection tools contributing to the surveillance of SFG rickettsiae in arthropods and animals are reviewed.
Keywords
Infectious disease, Tropical, Spotted Fever, Rickettsia, Vector-borne disease, Diagnostic
Divisions
fac_med,tidrec
Funders
Ministry of Education, Malaysia under the Higher Institution Centre of Excellence (HICoE) program [MO0022019],NewtonUngku Omar Fund partnership [332192305],UK Department of Business, Energy and Industrial Strategy (BEIS),Energy and Industrial Strategy and Malaysian IndustryGovernment Group for High Technology (MIGHT),Universiti Malaya, Malaysia [RUU002-2019]
Publication Title
Acta Tropica
Volume
218
Publisher
Elsevier
Publisher Location
RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS