A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
Document Type
Article
Publication Date
3-19-2021
Abstract
A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC50 values of 359 and 0.250 nM, respectively. GRAPHICS] .
Keywords
Xestospongia sp, Sterol, Kaimanol, Plasmodium falcifarum, Petrosiidae
Divisions
Science
Funders
BPPDN,Ministry of Research and Technology of the Republic of Indonesia (RISTEK)
Publication Title
Natural Product Research
Volume
35
Issue
6
Publisher
Taylor & Francis
Publisher Location
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND