Optic canal analysis in syndromic craniosynostosis: volumetric and surface area validation study using different measurement modalities
Document Type
Article
Publication Date
1-1-2021
Abstract
Background: In syndromic craniosynostosis (SC), unlike persistent corneal irritation due to severe exophthalmos and increased intracranial pressure, optic canal (OC) stenosis has been scarcely reported to cause visual impairment. This study aimed to validate the OC volumetric and surface area measurement among SC patients. Methods: Sixteen computed tomography scan of SC patients (8 months-6 years old) were imported to Materialise Interactive Medical Image Control System (MIMICS) and Materialise 3-matics software. Three-dimensional (3D) OC models were fabricated, and linear measurements were obtained. Mathematical formulas were used for calculation of OC volume and surface area from the 3D model. The same measurements were obtained from the software and used as ground truth. Data normality was investigated before statistical analyses were performed. Wilcoxon test was used to validate differences of OC volume and surface area between 3D model and software. Results: The mean values for OC surface area for 3D model and MIMICS software were 103.19 mm(2) and 31.27 mm(2), respectively, whereas the mean for OC volume for 3D model and MIMICS software were 184.37 mm(2) and 147.07 mm(2), respectively. Significant difference was found between OC volume (P = 0.0681) and surface area (P = 0.0002) between 3D model and software. Conclusion: Optic canal in SC is not a perfect conical frustum thus making 3D model measurement and mathematical formula for surface area and volume estimation not ideal. Computer software remains the best modality to gauge dimensional parameter and is useful to elucidates the relationship of OC and eye function as well as aiding intervention in SC patients.
Keywords
3D printing, CT scan, Optic canal, Syndromic craniosynostosis
Divisions
foundation,OralMaxillofacialSurgery,biomed
Funders
Universiti Malaya [BKS081-2017]
Publication Title
Journal of Craniofacial Surgery
Volume
32
Issue
1
Publisher
Lippincott Williams & Wilkins
Publisher Location
TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA