Chemicals Constituents Isolated from Cultivate Alpinia conchigera Griff. and Antimicrobial Activity
Document Type
Article
Publication Date
1-1-2020
Abstract
Alpinia conchigera Griff. is a plant species from the family Zingiberaceae. Coloquially known as wild ginger, Alpinia conchigera Griff. is used as food condiment and for traditional treatment of skin diseases. Isolation studies to identify bioactive compounds of rhizomes of Alpinia conchigera yielded seven compounds; 1‘S-1'-acetoxychavicol acetate (1), trans-p-coumaryl diacetate (2), p-hydroxycinnamyl acetate (3), 1‘S-1'-hydroxychavicol acetate (4) p-hydroxybenzaldehyde (5), stigmasterol (6) and β-sitosterol (7). Compounds 1, 2 and 5 were evaluated for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). Among the compounds tested, Compound 1 showed good antimicrobial activity against the strain of MRSA with minimum inhibition concentration (MIC) value of 0.5 mg/mL. Meanwhile, Compounds 2 and 5 exhibited moderate activity with MIC value between 1.0 and 2.0 mg/mL. These findings indicate antimicrobial potential of 1‘S-1'- acetoxychavicol acetate (1), compound derived from rhizome of Alpinia conchigera Griff. against MRSA, which warrant further investigation. © Penerbit Universiti Sains Malaysia, 2020.
Keywords
Alpinia conchigera griff., Antimicrobial, Methicilin resistant staphlococcus aureus, MRSA, Zingiberaceae
Divisions
CHEMISTRY
Funders
Universiti Sains Malaysia, Pulau Pinang for providing grant 304/PKIMIA/6313330
Publication Title
Tropical Life Sciences Research
Volume
31
Issue
1
Publisher
Penerbit Universiti Sains Malaysia