Telescopic Synthesis of Azo Compounds via Stable Arenediazonium Tosylates by Using n-Butyl Nitrite as Diazotization Reagent
Document Type
Article
Publication Date
1-1-2019
Abstract
A multi-step catalyst-free synthesis of azo compounds by using n-butyl nitrite as a diazotization reagent and p-toluene sulfonic acid as a mild acidic agent in ethanol/water mixed solvent was investigated. In the combined one-pot synthesis process, no nitrous acid was produced during the diazotization. By controlling the conditions in a continuous process, a 62–88% yield was obtained. The current method has the following advantages: reduce waste by avoiding solvent for the purification of products in the diazotization step; save energy, time, and cost; work under environmentally benign conditions, and produce a good amount of products with potential use as azo-dyes, pigments, and therapeutic agents. © 2017, © 2017 Taylor & Francis Group, LLC.
Keywords
Azo coupling reaction, enviromentally benign, Knoevenagel's method, stable arenediazonium salt, telescopic reaction
Divisions
nanotechnology
Funders
High Impact Research Grant (No. H-21001-F0032) for Scientific Research from University of Malaya, Malaysia
Publication Title
Polycyclic Aromatic Compounds
Volume
39
Issue
4
Publisher
Taylor & Francis