Renewable resources-based approach to biantennary glycolipids
Document Type
Article
Publication Date
1-1-2018
Abstract
A new synthesis approach towards biantennary lipids of Guerbet glycoside type was developed based on oleic acid as sustainable resource. Functionalization of the double bond provided access to primary alcohols with α-branched C19-skeleton. Formulation studies with corresponding lactosides indicated formation of vesicles with high assembly stability. A relatively narrow bimodal size distribution of the latter, which turns into a narrow unimodal distribution of small vesicles upon addition of an ionic cosurfactant, suggests potential for a vesicular drug delivery system.
Keywords
Oleic acid functionalization, Biantennary glycolipids, Guerbet glycosides, Biosurfactant assembly, Vesicles
Publication Title
Chemistry and Physics of Lipids
Divisions
CHEMISTRY
Funders
University of Malaya under grants RP024-2012B, RG264-13AFR, and PG149‐2015A,Malaysian Ministry of Education under research grant FP032-2013B
Volume
212
Publisher
Elsevier