Renewable resources-based approach to biantennary glycolipids
Document Type
Article
Publication Date
1-1-2018
Abstract
A new synthesis approach towards biantennary lipids of Guerbet glycoside type was developed based on oleic acid as sustainable resource. Functionalization of the double bond provided access to primary alcohols with α-branched C19-skeleton. Formulation studies with corresponding lactosides indicated formation of vesicles with high assembly stability. A relatively narrow bimodal size distribution of the latter, which turns into a narrow unimodal distribution of small vesicles upon addition of an ionic cosurfactant, suggests potential for a vesicular drug delivery system.
Keywords
Oleic acid functionalization, Biantennary glycolipids, Guerbet glycosides, Biosurfactant assembly, Vesicles
Divisions
CHEMISTRY
Funders
University of Malaya under grants RP024-2012B, RG264-13AFR, and PG149‐2015A,Malaysian Ministry of Education under research grant FP032-2013B
Publication Title
Chemistry and Physics of Lipids
Volume
212
Publisher
Elsevier