Functionalized glycolipids for potential bioconjugation of vesicles

Document Type

Article

Publication Date

1-1-2018

Abstract

Two azide-terminated oligoethylene oxide spacered glycolipids have been synthesized, and their assembly behavior has been studied in comparison to the corresponding base surfactants. The results suggest potential of the Guerbet lactoside-based compound for targeted drug delivery, while a coiling of the ethylene oxide linker disfavors the application of the glucoside.

Keywords

Biantennary glycolipid, Targeted drug delivery, Vesicle bioconjugation, CLICK chemistry coupling, Ethylene oxide spacer, Surfactant assembly

Divisions

CHEMISTRY

Funders

University of Malaya under grants RP024-2012B, RG264-13AFR, RG383-17AFR and PG093-2013A,Malaysian Ministry of Higher Education under research grant FP032-2013B

Publication Title

Carbohydrate Research

Volume

469

Publisher

Elsevier

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