Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Document Type

Article

Publication Date

1-1-2018

Abstract

Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.

Keywords

alkaloid, antineoplastic agent, bisleuconothine B, bisleuconothine C, bisleuconothine D, unclassified drug

Divisions

CHEMISTRY

Publication Title

Journal of Natural Products

Volume

81

Issue

11

Publisher

American Chemical Society

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