Document Type
Article
Publication Date
1-1-2011
Abstract
Despite being a complex degenerative joint disease, studies on osteoarthritis (OA) suggest that its progression can be reduced by the use of hyaluronic acid (HA) or mesenchymal stem cells (MSC). The present study thus aims to examine the effects of MSC, HA and the combination of HA-MSC in treating OA in rat model. The histological observations using O'Driscoll score indicate that it is the use of HA and MSC independently and not their combination that delays the progression of OA. In conclusion, the preliminary study suggest that the use of either HA or MSCs effectively reduces OA progression better than their combined use.
Keywords
Hyaluronic acid, Mesenchymal stem cells, Monosodium iodoacetate, Osteoarthritis rat model
Divisions
fac_med
Publication Title
Indian Journal of Experimental Biology
Volume
50
Additional Information
Department of Orthopaedic Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA