Angustilobine and andranginine type indole alkaloids and an uleine–secovallesamine bisindole alkaloid from Alstonia angustiloba

Authors

T.S. Kam
W.F. Ku
S.J. Tan
Y.Y. Low
K. Komiyama

Document Type

Article (Restricted)

Publication Date

1-1-2011

Abstract

A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline, derived from the union of uleine and secovallesamine moieties. The structures of these alkaloids were established using NMR and MS analysis. Angustilobine C showed moderate cytotoxicity towards KB cells.

Keywords

Apocynaceae, Alstonia angustiloba, Alkaloids, Bisindole, NMR, Cytotoxicity.

Divisions

CHEMISTRY

Publication Title

Phytochemistry

Volume

72

Publisher

Elsevier

Additional Information

Department of Chemistry, University of Malaya