DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex

Document Type

Article

Publication Date

1-1-2015

Abstract

A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism.

Keywords

Carboplatin, DNA interaction, HeLa cell, Intercalation mechanisms, Substituted thiophene, Thiosemicarbazone complexes, Thiosemicarbazones, Zinc complex

Divisions

CHEMISTRY,PHYSICS

Publication Title

Bulletin of the Chemical Society of Japan

Volume

88

Issue

8

Publisher

Chemical Society of Japan

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