Document Type
Article (Restricted)
Publication Date
1-1-2013
Abstract
This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus erythematosus (SLE) presented with a seizure followed by frontal lobe dysfunction clinically. An electroencephalogram (EEG) showed bilateral independent PLEDs in the frontal region. A magnetic resonance image of the brain showed white-matter changes in the frontal periventricular region. Cerebral angiogram did not reveal any evidence of vasculitis. A cerebral SPECT with tracer injected during the EEG showing PLEDs showed a reduction in CBF in the frontal regions. Clinical recovery was observed with intravenous immunoglobulin. This case shows that PLEDs can be seen with white-matter changes in SLE. Lupus (2013) 22, 510-514.
Keywords
PLEDs, SPECT, cerebral lupus, white matter
Divisions
fac_med
Funders
This work was supported by a University Malaya Research Grant (Reference No: RG 324/11HTM)
Publication Title
Lupus
Volume
22
Issue
5
Publisher
Arnold Publishers (journals now owned by Sage)
Additional Information
ISI Document Delivery No.: 122TV Times Cited: 0 Cited Reference Count: 13 Aye, S. M. M. Lim, K. S. Ramli, N. M. Tan, C. T. University Malaya RG 324/11HTM This work was supported by a University Malaya Research Grant (Reference No: RG 324/11HTM). Sage publications ltd London