Document Type
Article (Restricted)
Publication Date
1-1-2013
Abstract
The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 lg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 lg/mL) against B. cereus.
Keywords
Alpinia pahangensis Ridley, Zingiberaceae, Bis-labdanic diterpene, Labdane diterpene, Pahangensin A, Pahangensin B, Antibacterial agent
Divisions
InstituteofBiologicalSciences
Publication Title
Bioorganic and Medicinal Chemistry Letters
Volume
23
Publisher
Elsevier
Additional Information
Corresponding author. Tel.: +60 79674064; fax: +60 79674193. E-mail address: khalijah@um.edu.my (K. Awang). Department of Chemistry, Faculty of Science, University Malaya