Document Type
Article (Restricted)
Publication Date
1-1-2013
Abstract
A total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The structure and relative configurations of these alkaloids were established using NMR, MS and in several instances, confirmed by X-ray diffraction analysis. Six of these alkaloids were effective in reversing multidrug-resistance(MDR) in vincristine-resistant KB cells.
Keywords
Alstonia macrophylla, Apocynaceae, Indole alkaloids, NMR X-ray crystallography, Reversal of multidrug-resistance
Divisions
CHEMISTRY
Publication Title
Phytochemistry
Volume
98
Publisher
Elsevier
Additional Information
Department of Chemistry, University of Malaya