Document Type
Article
Publication Date
12-21-2012
Abstract
Eleven compounds:goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.
Keywords
Goniothalamus tapisoides, goniomicins A–D, tapisoidin, cytotoxicity, antioxidant activity
Divisions
fac_med
Funders
Institute of Research Management and Monitoring (IPPP) of University Malaya (No. PS339/2010A),FRGS of University Teknologi Mara (600-RMI/ST/FRGS5/3/Fst(135/2010),02(DPI02)/792/2011(02) of UNIMAS,UMRG Program (RP001/2012A) and (RP001/2012B)
Publication Title
Molecules Online
Volume
18
Issue
1
Publisher
Springer Verlag (Germany)