Document Type
Article
Publication Date
12-15-2012
Abstract
A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).
Keywords
Aglaia exima, Meliaceae, Cycloartane, Cytotoxicity, Steroids, 24(E)-cycloart-24-ene-26-ol-3-one
Divisions
fac_med
Funders
Institute of Research Management and Monitoring (IPPP) (PS344/2009C),Fundamental Research Grant Scheme (FRGS) (FP006/2011A),Research University Grant (RP001/2012A)
Publication Title
Fitoterapia
Volume
83
Issue
8
Publisher
Elsevier