Document Type
Article (Restricted)
Publication Date
1-1-2012
Abstract
Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 μM), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 μM. The action of (-)-limacine (4) was deduced to be mediated through the increased release of NO from endothelial cells, and that of pecrassipine A (7) and backebergine (12) partly mediated by NO release. Further, the action of pecrassipine A (7) and backebergine (12) may be attributed to their inhibition of the voltage-dependent Ca(2+) channel and receptor-operated Ca(2+) channel.
Keywords
Popowia perakensis, Phaeanthus crassipetalus, Vasorelaxant effect, Rat aortic artery, Isoquinoline alkaloids.
Divisions
CHEMISTRY
Publication Title
Journal of Natural Medicines
Volume
66
Publisher
Springer Verlag
Additional Information
Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia--- doi: 10.1007/s11418-011-0600-4