Document Type
Article (Restricted)
Publication Date
1-1-2010
Abstract
A total of 25 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia spatulata, of which five are new alkaloids of the strychnan type (alstolucines A-E, 1-5)and the other, a new alkaloid of the secoangustilobine A type(alstolobine A, 6). The structures of these alkaloids were established using NMR and MS analysis and, in the case of alstolucine B (2), also confirmed by X-ray diffraction analysis. A reinvestigation of the stereochemical assignment of scholaricine (13) by NMR and X-ray analyses indicated that the configuration at C-20 required revision. Alkaloids 1, 2, 6, 7, 9, 10, and 13 reversed multidrug resistance in vincristine-resistant KB cells.
Keywords
Alkaloids, NMR, Alstonia spatulata, Alstolucine.
Publication Title
Journal of Natural Products
ISSN
0163-3864
Recommended Citation
Kam, T.S.; Tan, S.J.; Low, Y.Y.; Choo, Y.M.; Abdullah, Z.; Etoh, T.; Hayashi, M.; and Komiyama, K., "Strychnan and secoangustilobine A type alkaloids from alstonia spatulata. Revision of the C-20 configuration of scholaricine" (2010). Research Publications (2006 to 2010). 4547.
https://knova.um.edu.my/research_publications_2006_2010/4547
Divisions
CHEMISTRY
Volume
73
Publisher
American Chemical Society and American Society of Pharmacognosy
Additional Information
Department of Chemistry, University of Malaya --- doi: 10.1021/np100552b