Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
Document Type
Article
Publication Date
1-1-2010
Abstract
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.
Publication Title
The Journal of Organic Chemistry
Volume
75
Issue
12
Publisher
American Chemical Society
Publisher Location
1155 16TH ST, NW, WASHINGTON, DC 20036 USA
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