Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii

Authors

• Y. Hirasawa
• T. Shoji
• T. Arai
• A.E. Nugroho
• J. Deguchi
• T. Hosoya
• N. Uchiyama
• Y. Goda
• K. Awang
• A.H.A. Hadi
• M. Shiro
• H. Morita

Document Type

Article

Publication Date

1-1-2010

Abstract

A new bisindole alkaloid, bisleuconothine A(1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A(1) showed cell growth inhibitory activity against various human cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.

Publication Title

Bioorganic & Medicinal Chemistry Letters

Recommended Citation

Hirasawa, Y.; Shoji, T.; Arai, T.; Nugroho, A.E.; Deguchi, J.; Hosoya, T.; Uchiyama, N.; Goda, Y.; Awang, K.; Hadi, A.H.A.; Shiro, M.; and Morita, H., "Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii" (2010). Research Publications (2006 to 2010). 3193.
https://knova.um.edu.my/research_publications_2006_2010/3193

Volume

20

Issue

6

Publisher

Elsevier