Document Type
Article (Restricted)
Publication Date
1-1-2003
Abstract
The role of surface activity has been studied in the mechanism of action of tricyclic antidepressants (TCAs). TCAs have been shown to generate liquid membranes in series with a supporting membrane by the virtue of their amphiphillicity. Transport of important biogenic amines (adrenaline, nor-adrenaline, dopamine and 5-hydroxy tryptamine) and ions (potassium, sodium and calcium) have been studied in the presence of liquid membranes generated by surface-active TCAs. The data on the modifications in the permeability of important biogenic amines and ions indicates that the liquid membranes generated by TCAs may play a significant role in the mechanism of their anti depressant action. The surface-active nature of the drugs has been discussed with relevance to their pharmacological effects. (C) 2003 Elsevier B.V. All rights reserved.
Keywords
Surface activity, Imipramine HCl, Clomipramine HCl, Amitriptyline HCl, Kesting's hypothesis, Liquid membrane hypothesis
Divisions
fac_med
Publication Title
Colloids and Surfaces B-Biointerfaces
Volume
32
Issue
3
Additional Information
Nagappa, AN Kole, PL Pandi, PV Shanmukha, I Girish, K Mishra, RPK