Document Type
Article (Restricted)
Publication Date
1-1-2003
Abstract
The liquid membrane hypothesis in anti-hypertensive drugs, namely, propranolol, metoprolol and atenolol have been investigated. Adreneceptor antagonist drugs have been shown to generate liquid membranes in series with a supporting membrane. Transport through liquid membrane generated by lecithin, cholesterol and lecithin-cholesterol mixture has been studied in the presence of adreneceptor antagonists. The data indicate that the transport of cations and neurotransmitters of physiological importance is impeded in presence of the liquid membrane. Relevance of this observation to anti-hypertensive action and anti-arrythmic action of these drugs has been discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
Keywords
Hydraulic permeability, Solute permeability, Liquid membrane, Critical micellar concentration (CMC)
Divisions
fac_med
Publication Title
Journal of Membrane Science
Volume
211
Issue
2
Additional Information
Nagappa, A Kole, PL Pandi, PV Girish, K Rahul, PK Shanmukha, I