Date of Award

1-1-2010

Thesis Type

Masters

Document Type

Dissertation

Divisions

Faculty of Science

Department

Department of Chemistry

Institution

Universiti Malaya

Abstract

The phytochemical study on the leaves and bark of Alseodaphne corneri (Lauraceae) involved extraction and separation of alkaloids by using various chromatographic methods. The structural elucidation of all the alkaloids were done using spectroscopic techniques such as 1D-NMR (1H, 13C, DEPT), 2D-NMR (COSY, NOESY, HMQC, HMBC), UV, IR, MS (GCMS, LCMS, HRMS) and comparison with the literature data.

Four aporphines isolated from the leaves of Alseodaphne corneri, were isocorydine 44, norisocorydine 45, N-methyl laurotetanine 46 and N-methyl lindcarpine 47. Isolation and purification of alkaloids from the bark of Alseodaphne corneri afforded six known alkaloids and one new alkaloid. The new bisbenzylisoquinoline alkaloid was named as 3’, 4’-dihydronorstephasubine 52. The known compounds were two aporphine alkaloids; laurotetanine 48 and norboldine 49 and four bisbenzylisoquinoline alkaloids; gyrolidine 50, norstephasubine 51, 7’-O-demethylstebisimine 53 and stephasubimine 54.

Four aporphines from the leaves of this species were tested for the antiplasmodial activity, and it was found that compound 46 exhibit most potent antiplasmodial activity with IC50 of 8.4 μM. Meanwhile, the bisbenzylisoquinoline alkaloids of 50, 51, and 52 from the bark of this species were tested for the antihypertensive activity. Gyrolidine 50 and 3’4’-dihydronorstephasubine 52 exhibited moderate vasorelaxant activity with 65% relaxation against contraction in the rat aorta strips.

Comments

Dissertation (M.A.) – Faculty of Science, Universiti Malaya, 2010.

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