Date of Award
11-1-2017
Thesis Type
masters
Document Type
Thesis
Divisions
medic
Department
Faculty of Medicine
Institution
University of Malaya
Abstract
As Asian patients with type 2 diabetes mellitus (T2DM) have significant beta cell dysfunction and increased visceral adiposity, we hypothesize that sodium glucose cotransporter inhibitors which acts independent from insulin dependent mechanisms, are effective in a multi ethnic T2DM population in real-world setting. A retrospective T2DM cohort (N=ll 0) treated with dapagliflozin for months was identified from the electronic pharmacy database. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI 2009 equation. Missing laboratory values were imputed utilizing the "last observation-carried-forward" method. The 6- and 12-month postinterventional differences in biochemical profiles were examined using linear mixed-effects model or Friedman test. The mean age [±standard deviation] and disease duration [± standard deviation] were 56.2±9.5 and 14.8±8.0 years, respectively; mean HbA1c [±S.D.] was 70±14 rnmoVmol (8.6± 1.3%), 43.6% were men, and 22.7% had existing cardiovascular disease. The proportions of participants based on ethnicity were Malay 31.8%, Chinese 29 .I% and Indian 33 .6%. At 12 months, there was a significant decline in HbA1c (Mdndifference -10 mmol/mol [- 0.9%], 95% CI -13 to -8 mmoVmol [1.2 to -0.7%], P
Note
Dissertation (M.A.) – Faculty of Medicine, University of Malaya, 2017.
Recommended Citation
Ho, Hee Kheen, "The effect of dapagliflozin on clinical, metabolic and renal parameters in type 2 diabetic patient in University of Malaya Medical Centre: A single centre experience / Ho Hee Kheen" (2017). Student Works (2010-2019). 4923.
https://knova.um.edu.my/student_works_2010s/4923