Date of Award

1-1-2012

Thesis Type

phd

Document Type

Thesis

Divisions

science

Department

Faculty of Science

Institution

University of Malaya

Abstract

Six new Schiff bases were prepared from the reaction of 4-phenyl-1,3,5-triazine-2,6-diamine with 5-chlorosalicyladehyde, 5-bromosalicyladehyde, 5-nitrosalicyladehyde, 3-hydroxysalicyladehyde, 4-hydroxysalicyladehyde, and 3,5-di-tert-butylsalicyladehyde. Each of these Schiff bases were then reacted with Ni(II), Cu(II), and Zn(II) acetates to the corresponding complexes (total 18). The Schiff bases were characterized by elemental analysis (CHN), Fourier transform infrared spectroscopy (FT-IR), 1H- and 13C- nuclear magnetic resonance spectroscopy (NMR), ultraviolet-visible spectroscopy (UV-vis), while the complexes were additionally characterized by CHN, FT-IR, UV-vis and thermogravimetric analysis (TGA). All Ni(II) complexes are octahedral, all Cu(II) complexes are square pyramidal, and all Zn(II) complexes are tetrahedral. The thermal stabilities of Ni(II) and Cu(II) complexes of H2L1, H2L2, H2L3 and H2L6 are similar (245-255oC), but slightly higher than those of the corresponding Zn(II) complexes (225-230oC), and significantly higher than those of H2L4 and H2L5 (200-210oC). The antioxidant activities of the Schiff bases and their complexes were measured in terms of their radical scavenging ability towards diphenylpicrylhydrazyl free radical (DPPH) and ferric reducing ability power (FRAP). All of the Schiff bases studied have higher antioxidant activities compared to the corresponding complexes. The Schiff bases with the highest antioxidant activities are H2L4 and H2L5, while the complexes with the highest antioxidant activities are NiL4 and NiL5. The antioxidant activities increase with concentration of the compounds.

Note

Thesis (Ph.D.) -– Faculty of Science, University of Malaya, 2012

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