Date of Award
1-1-2012
Thesis Type
masters
Document Type
Thesis
Divisions
science
Department
Faculty of Science
Institution
University of Malaya
Abstract
The chromatographic separation of the n-hexane extract from the stem bark of Walsura pinnata Hassk (Meliaceae) which was collected at Kuala Lipis, Pahang, led to the isolation of nine chemical constituents. Their structures were characterized to be ledol (115), oplopanone (116), betulonic acid (117), oleanonic acid (118), 3-oxoolean-11-en- 13β(28)-olide (119), 12α-hydroxy-3-oxooleanano-28,13-lactone (120), 3-oxoursolic acid (121), 3-ketours-11-en-13β(28)-olide (122), 3β-hydroxy-5-glutinen-28-oic acid (123). The structural elucidation of these compounds was determined by spectroscopic data interpretation. Betulonic acid (117) and 3β-hydroxy-5-glutinen-28-oic acid (123) were found to be cytotoxic against a series of human cancer cell lines with an IC50 = 19 μM, 18 μM on HepG2; 12 μM, 25 μM on MCF-7 and 13 μM, 21 μM on HSC-2 respectively.
Note
M.Sc. -- Jabatan Kimia, Fakulti Sains, Universiti Malaya, 2012
Recommended Citation
Yusoff, Mahfuzah, "Chemical constituents of Walsura pinnata hassk / Mahfuzah Yusoff" (2012). Student Works (2010-2019). 1320.
https://knova.um.edu.my/student_works_2010s/1320