Effect of artocarpus-integer lectin on functional-activity of guinea-pig complement

Document Type

Article

Publication Date

1-1-1994

Abstract

The effect of Artocarpus integer lectin (lectin C) on the functional activity of guinea-pig complement was investigated. Purified and crude extract of lectin C from six cultivars of Artocarpus integer seeds were found to consume complement and thus decreased the complement-induced haemolytic activity of sensitized sheep erythrocytes. The change in the complement-mediated haemolytic activity was significantly decreased when incubation of the lectins was performed in the presence of melibiose. The reversal effect of the carbohydrate, which is a potent inhibitor of the lectin's binding to O-linked oligosaccharides of glycoprotein, demonstrate involvement of the lectins interaction with O-glycans of glycoproteins in the consumption of guinea-pig complement.

Keywords

Molecular Medicine, Artocarpus-integer Lectin

Publication Title

Immunological Investigations

ISSN

0882-0139

Divisions

fac_med

Volume

23

Issue

2

Additional Information

Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

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