Interaction of artocarpus lectins with human-iga does not involve asparagine-linked oligosaccharide of the immunoglobulin

Document Type

Article

Publication Date

1-1-1992

Abstract

In view of the controversy with respect to the interaction of jacalin with human IgA2, a study was undertaken to assess the reactivity of the Artocarpus heterophyllus lectin, as well as the lectin from Artocarpus integer (lectin C), with subclasses of human immunoglobulin A by ELISA. Our data is consistent with the view that Artocarpus lectins have no affinity for the IgA2 immunoglobulins. In further support of the findings, we have established that N-linked oligosaccharide moieties of IgA have no significant bearing in the lectin-immunoglobulin binding. Interaction was also not affected in the presence of 1 (w/v) BSA.

Keywords

Molecular Medicine, Human IgA2

Publication Title

Biochemistry International

ISSN

0158-5231

Divisions

fac_med

Volume

27

Issue

3

Additional Information

Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

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