Combined prednisolone, azathioprine, and cyclophosphamide treatment for persistent proliferative glomerulonephritis in adults
Document Type
Article
Publication Date
1-1-1971
Abstract
Twelve adults-seven with nephrotic syndrome due to proliferative glomerulonephritis and five with persistent proliferative glomerulonephritis-were given prednisolone alone, or in combination with azathioprine or with azathioprine and cyclophosphamide. Prednisolone alone or with azathioprine did not produce remission but on the combined prednisolone/azathioprine/cyclophosphamide treatment ten patients recovered completely. No serious toxic reactions to this regimen were ob served. Triple-drug therapy seems to interfere with the immune process more effectively than double therapy. © 1971.
Keywords
Adolescent, Adult, Azathioprine, Chlorambucil, Cholesterol, Creatinine, Cyclophosphamide, Female, Glomerulonephritis, Human, Kidney Glomerulus, Male, Nephrotic Syndrome, Prednisolone, Prognosis, Proteinuria, Serum Albumin
Divisions
fac_med
Publication Title
The Lancet
Volume
298
Issue
7738
Publisher
Elsevier