Advances in 3D Printed Microneedles as a Prototype for Skin Targeted Therapeutics in Personalized Dermal Pharmaceuticals

Document Type

Review

Publication Date

1-1-2026

Abstract

In the evolving realm of skin delivery, the shortcomings of traditional drug delivery practices have encouraged the emergence of innovative therapeutics using next generation- 3D printed microneedles. Next-generation microneedles, fabricated using advanced 3D printing technology, offer a precise and targeted approach to overcome the challenges of poor skin penetration over traditional topical therapies. By creating micro-scale channels on the skin, 3D microneedles facilitate the efficient delivery of cosmeceuticals, addressing a spectrum of skin concerns such as atopic dermatitis, psoriasis, alopecia, skin tumors, diabetic wound, hyperpigmentation, wrinkles and acne scars. PubMed analysis reveals a significant rise in 3D printed microneedle publications from 10 in 2000 to over 350 in 2025, with more than 65 clinical trials registered between 2010 and 2025. The intersection of microneedle technology and dermatology presents a promising avenue for personalized treatment. We elucidated the latest advancements and future directions to guide researchers and clinicians toward the development of safe and effective drug delivery interventions in the ongoing battle against the severity of skin diseases. Furthermore, the prospects of 3D printed microneedles with ongoing advances in biomimetism indicate potential translation into reliable, and scalable pharmaceutical. Nevertheless, further research is warranted to optimize formulations, ensure biocompatibility, and unlock their full potential in revolutionizing the field.

Publication Title

AAPS Pharmscitech

DOI

10.1208/s12249-025-03295-1

Volume

27

Issue

1

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