Microalgae and Human Disorders: Mechanistic Insights and Therapeutic Potential

Document Type

Review

Publication Date

1-1-2026

Abstract

Microalgae, which are primarily autotrophic organisms, have caught the spotlight due to their impressive growth rates and broad distribution. They’re particularly exciting because of their biocompatibility and the wide range of biological activities they offer. Species like Spirulina and Chlorella exhibit high antioxidant, anti-inflammatory, antimicrobial, anticancer, antihypertensive, anti-lipidemic, and anti-diabetic properties, making them a promising element in therapeutics. This review discusses the bioactive compounds present in microalgae, including peptides, polysaccharides, and lipids, and their mechanisms of action in disease diagnosis and prognosis. In addition, emerging reports on the synergistic effects of microalgae bioactive compounds in enhancing immune and gut health are discussed. Despite this, challenges in the extraction, cultivation, and commercialization of microalgae-based bioactive compounds remain significant hurdles for a great extent of application. This review examines the challenges and proposes relevant approaches to improve bioavailability and to optimize the cultivation of microalgae. The review underscores the significance of microalgae-derived bioactive agents for pharmaceutical and biomedical applications.

Publication Title

Current Topics in Medicinal Chemistry

ISSN

15680266

DOI

10.2174/0115680266365289250701180840

Volume

26

Issue

2

First Page

143

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