Targeted Nanomedicine Approaches for Precision Cancer Therapy

Document Type

Review

Publication Date

1-1-2026

Abstract

Background: Chemotherapy and radiation therapy are two examples of the many serious drawbacks of traditional cancer therapies, including their systemic toxicity and lack of cancer cell selectivity. Drug delivery has been transformed by the development of nanotechnology, which has made it possible to create nanoparticles with exact control over their size, shape, and surface characteristics. By functionalizing these nanoparticles with targeting ligands, it is possible to maximize medication accumulation at the tumor location while reducing offtarget effects by selectively binding to cancer cell receptors. The object of this review is to conclude and summarize the updated information targeted nanomedicine and it’s its role in cancer drug discovery and treatment. Method: A comprehensive literature search was conducted using electronic databases to identify relevant studies published in peer-reviewed journals. The search terms included "targeted nanomedicine," "precision cancer therapy," "nanoparticle drug delivery," and related keywords. The selected articles were critically evaluated to extract key findings and insights into targeted nanomedicine approaches for cancer therapy. Result: The review highlights the remarkable progress made in the development of targeted nanomedicine platforms for precision cancer therapy. These include nanoparticle formulations for targeted delivery of chemotherapeutic drugs, nucleic acid-based therapeutics, and imaging agents. Moreover, innovative strategies such as stimuli-responsive nanoparticles and combination therapy approaches have shown great potential in overcoming drug resistance and improving treatment efficacy. Conclusion: Targeted nanomedicine holds great promise for revolutionizing cancer therapy by enabling the precise delivery of therapeutic agents to tumor tissues while minimizing systemic side effects. Continued research efforts aimed at optimizing nanoparticle design, understanding tumor biology, and translating preclinical findings into clinical applications are crucial for realizing the full potential of targeted nanomedicine in precision cancer therapy.

Publication Title

Research Journal of Pharmacy and Technology

ISSN

09743618

DOI

10.52711/0974-360X.2026.00069

Volume

19

Issue

1

First Page

472

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