Machine learning for mechanistic insights and optimization in CO₂ cycloaddition catalysis

Document Type

Review

Publication Date

1-25-2026

Abstract

Converting CO₂ into cyclic carbonates via cycloaddition with epoxides is a key catalytic process for sustainable chemical synthesis and carbon mitigation, with 100 % atom economy. Machine learning (ML) drives catalyst design, reaction optimization, and mechanistic insights, achieving predictive accuracies up to R² = 0.99. This review (2020–2025) covers ionic liquids, metal-organic frameworks, and single-atom catalysts, achieving > 90 % yields at ambient conditions with activation energies of 10–20 kcal/mol. Despite challenges like dataset biases, the novel UniDesc-CO2 framework scales datasets to > 10,000 entries using standardized descriptors and active learning. Explainable AI (e.g., SHAP) clarifies descriptors like anion nucleophilicity, advancing sustainable CO₂ cycloaddition catalysis for scalable processes.

Publication Title

Applied Catalysis A General

ISSN

0926860X

DOI

10.1016/j.apcata.2025.120679

Volume

710

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