Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations

Authors

• Sanjiv Mahadeva, Universiti Malaya
• Kewin Tien Ho Siah, Department of Medicine
• Uday C Ghoshal, Apollo Multispeciality Hospitals Kolkata
• Hidekazu Suzuki, Tokai University School of Medicine
• Yeong Yeh Lee, School of Medical Sciences, Universiti Sains Malaysia
• Kee Huat Chuah, Universiti Malaya
• Vincent Chung, Chinese University of Hong Kong, Faculty of Medicine
• Linda Zhong, School of Biological Sciences
• Benjamin Wei Rong Tay, Department of Medicine
• Ban Hong Ang, Universiti Malaya
• Ram Prasad Sinnanaidu, Universiti Malaya
• Tao Bai, Tongji Medical College of Huazhong University of Science and Technology
• Tadayuki Oshima, Okazaki City Medical Association
• Tanisa Patcharatrakul, Faculty of Medicine, Chulalongkorn University
• Sanjeev Sachdeva, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research
• Ping Huei Tseng, National Taiwan University Hospital
• Jinsong Liu, Tongji Medical College of Huazhong University of Science and Technology
• Yinglian Xiao, Sun Yat-Sen University

Document Type

Review

Publication Date

3-1-2026

Abstract

Background: Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD. In this consensus report, members of ANMA and APAGE provide updated recommendations on the definition, diagnosis, epidemiology, pathophysiology, and management of FD, focusing on Asian populations. Methods: The task force members conducted a systematic literature review and used a modified Delphi process to develop updated consensus statements. Based on members' feedback, statements that failed to reach at least 80% consensus in the first round of voting were revised. Revisions included rephrasing for clarity, incorporating additional evidence, and subgroup voting during a second round of discussion at a hybrid meeting. Results: The task force developed 32 statements covering key aspects of FD. Major updates include new insights into the pathophysiology and emerging treatment options. The task force acknowledged that the limited scope and heterogeneity of available studies limit definitive conclusions about the utility of some emerging therapies such as probiotics and potassium-competitive acid blockers in FD management. Conclusions: The second Asian Consensus Report on FD provides updated evidence-based recommendations to improve the diagnosis and management of FD in clinical practice, particularly in the Asian setting.

Publication Title

Journal of Gastroenterology and Hepatology Australia

ISSN

08159319

DOI

10.1111/jgh.70222

Recommended Citation

Mahadeva, Sanjiv; Siah, Kewin Tien Ho; Ghoshal, Uday C; Suzuki, Hidekazu; Lee, Yeong Yeh; Chuah, Kee Huat; Chung, Vincent; Zhong, Linda; Tay, Benjamin Wei Rong; Ang, Ban Hong; Sinnanaidu, Ram Prasad; Bai, Tao; Oshima, Tadayuki; Patcharatrakul, Tanisa; Sachdeva, Sanjeev; Tseng, Ping Huei; Liu, Jinsong; and Xiao, Yinglian, "Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations" (2026). Research Publications (2026 to 2030). 198.
https://knova.um.edu.my/research_publications_2026_2030/198

Volume

41

Issue

3

First Page

832