The multifaceted roles of fibronectin in viral pathogenesis
Document Type
Review
Publication Date
3-1-2026
Abstract
Fibronectin is a high molecular weight glycoprotein critical to numerous physiological and pathological processes, including extracellular matrix organization, wound healing, immune responses, and interactions with pathogens. Evidence from various viral systems, including dengue, influenza, hepatitis B, and HIV-1, indicates that targeting fibronectin or disrupting its interactions can notably affect outcomes of viral infections in vitro. Alterations in the expression of fibronectin are associated with immune evasion mechanisms, including the inhibition of interferon signaling, thereby enabling viruses to survive and replicate with greater efficacy. In this review, we discuss how viruses can interact with fibronectin through arginyl-glycyl-aspartic acid motif (RGD) mimicry or other mechanisms. Finally, we explore the role of fibronectin in modulating host immune responses and its potential as a therapeutic target.
Publication Title
Archives of Virology
ISSN
03048608
DOI
10.1007/s00705-026-06546-z
Recommended Citation
Alenezi, Munirah Faleh; Khairat, Jasmine E.; Aziz, Muhamad Afiq; and Hassandarvish, Pouya, "The multifaceted roles of fibronectin in viral pathogenesis" (2026). Research Publications (2026 to 2030). 173.
https://knova.um.edu.my/research_publications_2026_2030/173
Volume
171
Issue
3