Phytochemistry and pharmacological potential of the genus Prismatomeris

Document Type

Article

Publication Date

1-13-2026

Abstract

The genus Prismatomeris, comprising 17 species in the Rubiaceae family and native to Southeast Asia, has been traditionally used to treat various ailments, including inflammatory disorders, hepatitis, and kidney dysfunction. Phytochemical studies consistently show that anthraquinones and their derivatives are the predominant secondary metabolites, accompanied by triterpenoids, iridoid glycosides, flavonoids, steroids, and several structurally distinctive constituents, such as prisconnatanones and prismatomerin. These metabolites exhibit diverse biological activities, including anticancer, anti-inflammatory, antibacterial, antituberculosis, antifungal, antimalarial, and antiviral effects, with anthraquinones and triterpenoids emerging as key bioactive classes. Despite promising pharmacological evidence, further comprehensive studies are needed to explore their mechanisms and therapeutic potential. Collectively, Prismatomeris represents an underexplored reservoir of bioactive natural products with significant therapeutic potential.

Keywords

Root, Santhraquinones, Connata, Tetrahydroanthraquinones, Cytotoxicity, Glycosides

Publication Title

ACS Omega

ISSN

2470-1343

DOI

10.1021/acsomega.5c10436

Volume

11

Issue

1

First Page

32

Last Page

45

Publisher Location

American Chemical Society

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