Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering
Document Type
Article
Publication Date
1-1-2021
Abstract
Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass (R) (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS parameters avoided undesirable reactions between the calcium phosphate (CaP) and bioglass (BG present in the form of powder and fibres), as confirmed through X-ray diffraction analysis. Scanning electron microscopy images of the composite scaffolds revealed a fibre like appearance of the glassy region. The in vitro bioactivity and biodegradation analyses were performed by immersing the composites in simulated body fluid (SBF) and tris(hydroxymethyl)aminomethane (Tris), respectively. The ability to obtain only the CaP phase and glassy phase with desirable bioactive and biodegradation behaviour, indicated that these SPS scaffolds can be employed as bone scaffolds for clinical trials, after further in vivo analyses.
Keywords
Hydroxyapatite, Bioglass (R), Spark plasma sintering, Bioactivity, Biodegradation
Divisions
fac_eng
Funders
NED Seed funding,Fundamental Research Grant Scheme (FRGS)[1/2020/Stg05/Unisza/02]
Publication Title
Processing and Application of Ceramics
Volume
15
Issue
3
Publisher
Faculty of Technology, University of Novi Sad
Publisher Location
BUL CARA LAZARA 1, NOVI SAD, 21000, SERBIA